Chemie und Biotechnologie anwendungsorientiert an der Hochschule Darmstadt (h_da) studieren

Equipment

The laboratory is ideally equipped for the production of protein targets using genetically modified E. coli bacteria. A wide range of biochemical/chromatographic methods are available for the purification of proteins. The functionality of the proteins is checked using various biological test methods. Sufficient quantities of highly purified target proteins are used to screen the in-house drug library for substances that inhibit the respective target protein. The binding of effective substances to their target protein is then examined in detail in order to identify suitable chemical lead structures for further development and optimization into drugs.

Schweipert M, Jänsch N, Upadhyay N, Tilekar K, Wozny E, Basheer S, Wurster E, Müller M, C S R, Meyer-Almes FJ. Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4. Pharmaceuticals (Basel). 2021, 14:1032. doi: 0.3390/ph14101032.
Upadhyay N, Tilekar K, Safuan S, Kumar AP, Schweipert M, Meyer-Almes FJ, C S R. Multi-target weapons: diaryl-pyrazoline thiazolidinediones simultaneously targeting VEGFR-2 and HDAC cancer hallmarks. RSC Med Chem. 2021, 12:1540-1554. doi: 10.1039/d1md00125f.
Tilekar K, Hess JD, Upadhyay N, Bianco AL, Schweipert M, Laghezza A, Loiodice F, Meyer-Almes FJ, Aguilera RJ, Lavecchia A, C S R. Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects. J Med Chem. 2021, 64:6949-6971. doi: 10.1021/acs.jmedchem.1c00491.

Laborleitung
Prof. Dr. Franz-Josef Meyer-Almes

Communication Stephanstraße 7
64295 Darmstadt
Office: B15, 1.05