Meyer-Almes - Research for practice

The interaction between the largest known protein titin and MuRF1 is thought to be responsible for cardiac muscle elasticity. Disruption of this protein-protein interaction is considered a promising approach for the therapy of diastolic heart failure. At the same time, histone deacetylase inhibitors are known to contribute to improved cardiac muscle elasticity in animal models. These relationships will be investigated in this research-for-practice project.